血管生成PCR芯片可用于研究與血管生成的生物學過程相關的84個基因。該芯片包括生長因子及其受體、趨化因子、細胞因子、細胞基質(zhì)、粘附分子、蛋白酶及其抑制劑，以及轉(zhuǎn)錄因子等參與新血管的生成的關鍵基因。血管生成是多種疾病的病理征兆，如癌癥、貧血、動脈粥樣硬化，及炎性疾病。血管生成還在正常發(fā)育及成人的生理過程中發(fā)揮重要作用，如傷口的愈合和組織再生。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測血管生成相關基因的表達。
Angiogenic Factors: Growth Factors and Receptors: ANG, ANGPT1, ANGPT2, ANPEP, TYMP, FGF1, FGF2 (bFGF), FIGF (VEGFD), FLT1, JAG1, KDR, NRP1, NRP2, PGF, VEGFA, VEGFB, VEGFC. Adhesion Molecules: BAI1, COL4A3, IL8, NRP1, NRP2. Proteases, inhibitors and Other Matrix Proteins: ANGPTL4, F3, PECAM1, PF4, PROK2, SERPINE1 (PAI-1), SERPINF1. Other Genes: HIF1A, NOS3, SPHK1. Other Factors Involved in Angiogenesis: Cytokines: CCL11 (Eotaxin), CCL2 (MCP-1), CXCL1, CXCL10 (INP10), CXCL5 (ENA78/LIX), CXCL6 (GCP-2), CXCL9 (MIG), EDN1, IFNA1, IFNG, IL1B, IL6, MDK, TNF. Growth Factors and Receptors: CTGF, EFNA1, EFNB2, EGF, EPHB4, FGFR3, HGF, IGF1, ITGB3, PDGFA, S1PR1, TEK (TIE2), TGFA, TGFB1, TGFB2, TGFBR1. Adhesion Molecules: CCL11 (Eotaxin), CCL2 (MCP-1), CDH5, COL18A1, CTGF, ENG (EVI-1), ERBB2 (HER2), FN1, ITGAV, ITGB3, S1PR1, THBS1, THBS2. Proteases, Inhibitors and Other Matrix Proteins: LECT1, LEP, MMP14, MMP2, MMP9, PLAU (uPA), PLG, TIMP1, TIMP2, TIMP3. Other Genes: AKT1, HPSE, ID1, NOTCH4, PTGS1, TIE1. |
